Nevertheless, Aureliano falls in love with Remedios Moscote, daughter of magistrate' head Don Apolinar Moscote. They become close to each other, but Aureliano, exhausted by prolonged scientific findings falls into insanity for quite a long time, having horrible visions about his future. Aureliano marries Remedios when she reaches puberty age and they live happily in the house of Aureliano's parents. Remedios raises Aureliano's illegitimate son from Pilar Ternera. Rebecca and Pietro Crespi start preparation for wedding ceremony but Remedios dies suddenly and the whole family is in mourning. Mourning is broken by the return of Jose Arcadio, who had changed much and became a tattooed masculine man. Jose Arcadio has affair with Rebecca, which later turns into marriage and exile caused by the will of his outraged mother Ursula. Meanwhile Pietro and Amaranta Buend'a experience revival of feelings for each other. Solitude and grief of Aureliano caused by the death of his wife is interrupted...

Aureliano joins troops of Liberals and later becomes their leader, known as Colonel Aureliano Buend'a. Aureliano leaves the son of his older brother Jose Arcadio and Pilar Terner in charge of Macondo, while he is absent. Arcadio turns into a cruel dictator and is later executed by a firing squad, when Conservatives captured town. Earlier Arcadio married Santa Sof'a de la Piedad, who gave birth to his sons and daugther: Aureliano Segundo, Jose Arcadio Segundo and Remedios the Beauty. Liberals lost first civil war and Colonel Aureliano Buendia together with his friend Gerineldo Marquez are captured and sentenced to execution. Colonel Aureliano Buendia has final request to be executed in his home town of Macondo, where he is finally rescued by his brother Jose Arcadio. Right after the escape from death, colonel Aureliano Buendia starts a new rebel.
One hundred years of solitude